Changes in version 2.4.1 (2023-03-22) - Fixed minor native routine registration issue. - Drop defunct CI services. - Update link to paper. Changes in version 2.4.0 (2021-12-08) - Add FWD() function for performing forward regressions. Changes in version 2.3.0 (2021-10-05) - Add segments() function for finding non-overlapping segments based on a summary statistic. - preprocess(): Add nCores parameter. - findRelated(): Map indices to sample names for matrix inputs. - getG(): Add impute parameter. - getG(): Impute by mean instead of 0 if center = FALSE. - getG(): Use preprocess() internally for better performance. - as.BGData(): Read genetic distances in .bim file as double instead of integer. Changes in version 2.2.0 (2020-08-02) - Follow [Bioconductor S4 practices][1]. - If you have used new() to create BGData instances, please use the BGData() constructor function instead. - If you have used @ to access the slots of BGData instances, please use the geno(), pheno(), and map() accessors instead. - BGData(): - Do not create dimnames for geno as this object is likely shared. - Check if geno has row names before creating pheno stub. - Check if geno has column names before creating map stub. - Rename IID in pheno stub to sample_id. - Rename mrk in map stub to variant_id. - Change format of rownames for pheno stub to a sequence starting with sample_ and rownames for map stub to a sequence starting with variant_ if geno does not have dimnames. - as.BGData(): - Force column classes when loading .fam and .bim files. - Force FID and IID columns to be of type character when loading alternate phenotype files. - Do not make assumptions about the structure of dimnames of a BEDMatrix object if it is passed without .fam and .bim file unless they are NULL. - Add validity tests for BGData objects: - Check if number of rows of geno matches number of rows of pheno. - Check if number of columns of geno matches number of rows of map. - Warn if the row names of pheno do not match the row names of geno. - Warn if the row names of map do not match the column names of geno. - Add preprocess() function for fast centering, scaling, and imputation. - GWAS(): Return number of records used for each variant and allele frequencies in rayOLS. - Update citation instructions. - Use inherits(., *) instead of class(.) == * (R4 compat). Changes in version 2.1.0 (2019-01-25) - Add chunkedMap() function. - Improve error handling in chunkedMap() and chunkedApply(). - summarize(): Improve performance. - GWAS(): Improve performance of rayOLS method. - GWAS(): Fix bug when computing p-values for methods other than rayOLS, lsfit, or SKAT when i is used to subset samples. - GWAS(): Fix wrong results in lsfit method when covariates with missing values are used. - as.BGData(): Fix bug loading .fam and .bim files when path contains the word bed. Changes in version 2.0.0 (2018-08-24) Breaking Changes - Rename bufferSize to chunkSize. - Remove nTasks parameter from chunkedApply() and methods based on it. - Remove crossprods function. Other Changes - Change chunking strategy to improve parallelism: instead of loading a subset of chunkSize in the main process, load a subset of chunkSize in the each fork. That way nTasks is not necessary anymore and the same code can be used for one core and multiple cores. - Add findRelated() function for use with matrices and symDMatrix objects. - Add orderedMerge() function that allows for phenotypes to be easily merged into a BGData object. - Performance improvements in getG() function: use single shared memory matrix to collect results. - Performance improvements in rayOLS method in GWAS() function. - getG_symDMatrix(): Support version 2 of symDMatrix package. - getG_symDMatrix(): Add chunkSize parameter. - getG_symDMatrix(): Add minVar parameter. - as.BGData(): Use rownames of BEDMatrix object as rownames for pheno, and colnames of BEDMatrix object as rownames for map. - Include process ID in verbose output if nCores > 1. Bug Fixes - getG_symDMatrix(): Fix scaling error when scale = FALSE. - getG_symDMatrix(): Compute block indices correctly for out-of-order, non-sequential indices. - getG_symDMatrix(): Do not include centers and scales in attributes anymore because the influence of j and minVar is difficult to retain. Changes in version 1.0.0 (2017-05-11) Initial release.